Electronic cigarettes (e-cigarettes) and traditional cigarettes differ significantly in their mechanism, composition, and health implications.
Mechanism of Action
Traditional Cigarettes: These involve the combustion of tobacco. When lit, tobacco burns, producing smoke that the user inhales. This smoke contains thousands of chemical compounds, many of which are harmful.

Electronic Cigarettes: These devices heat a liquid (e-liquid or vape juice) to create an aerosol, often referred to as vapor, which is then inhaled. No combustion takes place.
Composition and Key Substances
- Traditional Cigarettes:
- Tobacco: The primary component.
- Nicotine: A highly addictive stimulant naturally found in tobacco.
- Tar: A sticky, brown substance formed during combustion, containing numerous carcinogens.
- Carbon Monoxide: A toxic gas that reduces the oxygen-carrying capacity of blood.
- Other Harmful Chemicals: Thousands of other chemicals, including known carcinogens like benzene, formaldehyde, and arsenic, are produced during burning.
- Electronic Cigarettes:
- E-liquid: Typically contains:
- Nicotine: Most e-liquids contain nicotine, though nicotine-free options exist. Levels can vary.
- Propylene Glycol (PG) and Vegetable Glycerin (VG): Solvents that create the aerosol when heated. Generally recognized as safe for ingestion but long-term inhalation effects are still being studied.
- Flavorings: A wide variety of food-grade flavorings are used. Some flavorings, while safe to eat, may have different effects when inhaled.
- Harmful Substances (Potential): While e-cigarette aerosol generally contains fewer toxic substances than tobacco smoke, it is not harmless. It can contain harmful and potentially harmful substances, including heavy metals like nickel and tin, volatile organic compounds, and some carcinogens, though typically at lower levels than in cigarette smoke.
- E-liquid: Typically contains:
Health Implications
Traditional Cigarettes:
- Extensively proven to cause a wide range of serious health problems, including various cancers (lung, throat, mouth, etc.), cardiovascular diseases (heart attack, stroke), respiratory diseases (COPD, emphysema, chronic bronchitis), and negative reproductive outcomes.
- Responsible for premature death and significant disability worldwide.
Electronic Cigarettes:
- Generally considered less harmful than traditional cigarettes for existing adult smokers who switch completely. However, they are not risk-free.
- Long-term health effects are still under investigation as e-cigarettes are a relatively new product category.
- Nicotine exposure poses risks, especially to developing brains (adolescents and young adults), pregnant women, and individuals with heart conditions.
- Concerns exist regarding lung injury associated with some vaping products (e.g., EVALI, often linked to THC-containing products with Vitamin E acetate).
- Potential for initiation of nicotine use among non-smokers, particularly youth.
Secondhand Exposure
Traditional Cigarettes: Secondhand smoke contains numerous carcinogens and toxins, posing significant health risks to non-smokers.
Electronic Cigarettes: Secondhand aerosol (or vapor) contains nicotine, ultrafine particles, and other potentially harmful substances, though generally at lower levels than secondhand smoke. The long-term impact of secondhand aerosol exposure is still being researched, but it is not considered harmless.
Addiction Potential
Both traditional cigarettes and most electronic cigarettes contain nicotine, which is highly addictive. The delivery mechanism and nicotine concentration can influence the addictive potential.